Association of plasma aflatoxin with persistent detection of oncogenic human papillomavirus in cervical samples from Kenyan women enrolled in a longitudinal study | BMC Infection

Sub Levels


  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. World cancer statistics 2018: GLOBOCAN estimates worldwide incidence and mortality for 36 cancers in 185 countries. doing. CA Cancer J Clinic. 2018; 68:398–424.

    Google scalar

  • Stelzle D, Tanaka LF, Lee KK, et al. Estimates of the global burden of HIV-related cervical cancer. Lancet Grob Health. 2020; 9:161–9.

    Google scalar

  • Mwenda V, Mbul W, Bor JP, et al. Cervical Cancer Program, Kenya, 2011-2020: Lessons to guide elimination as a public health problem. E cancer medicine. 2022; 16:1442.

    PubMed PubMed Central Google Scholar

  • organization WH. Cervical cancer Kenya 2021 country profile. Available at https://www.who.int/publications/m/item/cervical-cancer-ken-country-profile-2021.

  • Brouwer V. AIDS-related cancers are on the rise in Africa. National Cancer Institute 2011;103:918–9.

    PubMed Google Scholar

  • Walboomers JM, Jacobs MV, Manos MM, and others Human papillomaviruses are obligatory causes of invasive cervical cancer worldwide.[see comment]. J. Pasol. 1999; 189:12–9.

    CAS PubMed Google Scholar

  • Kjaer SK, Frederiksen K, Munk C, Iftner T. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or greater after human papillomavirus infection: the role of persistence. National Cancer Institute 2010;102:1478–88.

    PubMed PubMed Central Google Scholar

  • Stelzle D, Tanaka LF, Lee KK, et al. Estimates of the global burden of HIV-related cervical cancer. The Lancet Global Health. 2021;9:e161–e9.

    CAS PubMed Google Scholar

  • Liu G, Sharma M, Tan N, Barnabas RV. HIV-positive women are at increased risk of human papillomavirus infection, precancerous lesions, and cervical cancer. AIDS. 2018;32:795–808.

    PubMed Google Scholar

  • Ermel A, Tonui P, Titus M, et al. Cross-sectional analysis of factors associated with detection of oncogenic human papillomaviruses in human immunodeficiency virus-infected and uninfected Kenyan women. BMC Infection 2019;19:352.

    CAS PubMed PubMed Central Google Scholar

  • Tong Y, Tonui P, Ermel A, et al. Persistence of oncogenic and non-oncogenic human papillomaviruses is associated with human immunodeficiency virus infection in Kenyan women. SAGE Open Med. 2020;8:2050312120945138.

    PubMed PubMed Central Google Scholar

  • Gong YY, Wilson S, Mwasa JK et al. Exposure to aflatoxin may contribute to chronic hepatomegaly in Kenyan schoolchildren. Environmental health perspective. 2012; 120:893–6.

    CAS PubMed PubMed Central Google Scholar

  • Seetha A, Monyo ES, Tsusaka TW et al. Aflatoxin-lysine adducts in the serum of rural Malawians and aflatoxin contamination in food (peanuts, maize) from the corresponding regions. Mycotoxin Res. 2018;34:195–204.

    CAS PubMed Google Scholar

  • Watson S, Moore SE, Durbo MK, etc. Stunting in rural Gambian infants exposed to aflatoxin: a prospective cohort study. BMC Public Health. 2018; 18:1247.

    CAS PubMed PubMed Central Google Scholar

  • Zhang J, Orang’o O, Tonui P, et al. Plasma aflatoxin detection and concentrations are associated with oncogenic human papillomavirus detection in Kenyan women. Open forum infected diss. 2019;6(9):ofz354. https://doi.org/10.1093/ofid/ofz354.

  • Tong Y, Orang’o E, nakalembe M, and others. East African Consortium on Human Papillomavirus and Cervical Cancer in Women Living with HIV/AIDS. Ann Med 2022;54:1202–11.

    CAS PubMed PubMed Central Google Scholar

  • Brown DR, Hsu ML, Kadadri B, et al. Longitudinal study of genital human papillomavirus infection in a closely followed cohort of adolescent females. J Infectious Disorders 2005;191:182–92.

    PubMed Google Scholar

  • WHO. human papillomavirus. His IARC Working Group on the Assessment of Carcinogenic Risk to Humans. IARC Monogram. 2007;90:1–636.

    Google scalar

  • Munoz N, Bosch FX, De San Jose S, et al. Epidemiological classification of human papillomavirus types associated with cervical cancer. N English J Med 2003;348:518–27.

    PubMed Google Scholar

  • McCoy LF, Sholl PF, Sutcliffe AE et al. Human aflatoxin albumin adducts were quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry. Cancer Epidemiol Biomarker 2008;17:1653–7.

    CAS PubMed Google Scholar

  • Smith JW, Kroker-Lobos MF, Lazo M, et al. Exposure to aflatoxin and viral hepatitis in Guatemala: Molecular biomarkers reveal a unique profile of risk factors in a region with high incidence of liver cancer. PLoS ONE. 2017;12:e0189255.

    PubMed PubMed Central Google Scholar

  • Groupman JD, Egner PA, Schulze KJ, et al. Aflatoxin exposure during the first 1000 days of life in rural South Asia as assessed by the aflatoxin B(1)-lysine albumin biomarker. Food chemical toxicity. 2014;74:184–9.

    CAS PubMed PubMed Central Google Scholar

  • Kosior J, Lindsay L, Pimenta JM, Poole C, Jenkins D, Smith JS. Persistent human papillomavirus infection and cervical tumors: a systematic review and meta-analysis. J Epidemiol. 2008; 168:123–37.

    PubMed PubMed Central Google Scholar

  • Stensen S, Keir SK, Jensen SM, et al. Factors associated with type-specific persistence of high-risk human papillomavirus infection: a population-based study. International J cancer. 2016; 138:361–8.

    CAS PubMed Google Scholar

  • Bennett JW, Klich M. Mycotoxins Clin Microbiol Rev. 2003;16:497–516.

    CAS PubMed Google Scholar

  • Wild CP, Gon YY. Mycotoxins and human disease: a largely ignored global health problem. carcinogenic. 2010;31:71–82.

    CAS PubMed Google Scholar

  • Turner PC, Moore SE, Hall AJ, Prentice AM, Wilde CP. Altered immune function following dietary aflatoxin exposure in Gambian children. Environmental health perspective. 2003; 111:217–20.

    CAS PubMed PubMed Central Google Scholar

  • Mesonnier GM, Pinton P, Lafite J et al. Immunotoxicity of aflatoxin B1: impairment of cell-mediated responses to vaccine antigens and regulation of cytokine expression. Poison application drug. 2008;231:142–9.

    CAS PubMed Google Scholar

  • Jolly PE. Aflatoxin: Does It Contribute to Increased HIV Viral Load? The Microbe of the Future. 2014; 9:121–4.

    CAS PubMed Google Scholar

  • Sirani K, Zanjani BR, Mahmudi M, et al. Immunotoxicity of aflatoxin M1: as a potent suppressor of the innate and acquired immune system in subacute studies. J Sci Food Aguri. 2018;98:5884–92.

    CAS PubMed Google Scholar

  • Chu YJ, Yang HI, Wu HC et al. Exposure to aflatoxin B1 increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption. Euro J Cancer. 2018; 94:37–46.

    CAS PubMed PubMed Central Google Scholar

  • Rush BR, Selim MI. Aflatoxin B1: A review of metabolism, toxicity, occurrence in food, occupational exposure, and methods of detoxification. Food chemical toxicity. 2019; 124:81–100.

    CAS PubMed Google Scholar

  • Carvajal M, Berumen J, Guardado-Estrada M. Presence of aflatoxin B(1)-FAPY adducts and human papillomavirus in cervical smears of Mexican cancer patients. Food Additive Contamination Part A Chemical Anal Control Expo Risk Assessment. 2012;29:258–68.

    CAS PubMed Google Scholar

  • Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. Human aflatoxinosis in developing countries: a review of toxicology, exposure, potential health effects, and interventions. I’m J. Klein Nuttall. 2004;80:1106–22.

    CAS PubMed Google Scholar

  • Wagacha JM, Musomi JW. The Mycotoxin Problem in Africa: Current Status, Food Safety and Health Impacts, and Possible Control Strategies. Int J food microbes. 2008; 124:1–12.

    CAS PubMed Google Scholar

  • Gnonlonfin GJ, Hell K, Adjovi Y et al. A review of aflatoxin pollution and its effects in the developing world: a perspective from sub-Saharan Africa. Crit Rev Food Sci Nutr. 2013;53:349–65.

    CAS PubMed Google Scholar

  • Leroy JL, Wang JS, Jones K. Serum aflatoxin B(1) lysine adduct levels in adult women in Eastern Kenya depend on household socioeconomic status: a cross-sectional study. Soc Sci Med. 2015; 146:104–10.

    PubMed Google Scholar

  • Ba DM, Ssentongo P, Musa J et al. Prevalence and determinants of cervical cancer screening in five sub-Saharan African countries: a population-based study. Cancer Epidemiol. 2021;72:101930.

    PubMed PubMed Central Google Scholar

  • Chilwa GC. Describe the socioeconomic inequalities in cervical cancer screening rates in Malawi. BMC Public Health. 2022;22:1376.

    PubMed PubMed Central Google Scholar

  • Groupman JD, Kensler TW, Wild CP. Preventive interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Pastor Anu Public Health Service. 2008;29:187–203.

    PubMed Google Scholar

  • Peles F, Sipos P, Kovacs S, Godori Z, Pocsi I, Pusztahelyi T. Biological control and mitigation of aflatoxin contamination in commodities. Toxin (Basel). 2021;13(2):104. https://doi.org/10.3390/toxins13020104.

    Papers CAS PubMed Google Scholar

  • Sipos P, Peles F, Brasso DL, et al. Physical and chemical methods for reducing the aflatoxin content of feeds and foods. Toxin (Basel). 2021; 13(3):204. https://doi.org/10.3390/toxins13030204.

    Papers CAS PubMed Google Scholar

  • Saeed F, Nadeem M, Ahmed R, Nadeem M, Arshad M, Ullah A. Studies of nutritional immunological influences underlying modulation of immune responses by nutritional compounds – review. Food and Agricultural Immunology. 2016;27:205–29.

    CAS Google scalar

  • Gravit PE. Evidence and impact of human papillomavirus incubation period. Open Virol J. 2012;6:198–203.

    PubMed PubMed Central Google Scholar

  • Weaver B, Shu M, Kadadri B, et al. Persistence of low levels of human papillomavirus 16 DNA in a closely followed cohort of adolescent females. J. Med Virol. 2011;83:1362–9.

    CAS PubMed Google Scholar

  • Ermel A, Shew ML, Imburgia TM, et al. Redetection of cervical human papillomavirus type 16 infection in mid-adulthood. Papillomavirus Institute 2018;5:75–9.

    PubMed PubMed Central Google Scholar

  • Paul P, Hammer A, Rosic AF, et al. Detection and undetection rates of novel human papillomaviruses in middle-aged women by recent and past sexual behavior. J Infectious Disorders 2021;223:1423–32.

    PubMed Google Scholar



  • Source link

    Leave a Reply

    Your email address will not be published. Required fields are marked *